Anti-SIGLEC7 antibody (51-100 aa) (STJ96646)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human SIGLEC7 at the amino acid range 51-100
General Information
| Short Description | Rabbit polyclonal anti-Sialic acid-binding Ig-like lectin 7 (51-100 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC-P 1:100-300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SIGLEC7 |
| Gene ID | 27036 |
| Uniprot ID | SIGL7_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human SIGLEC7 at the amino acid range 51-100 |
| Immunogen Region | 51-100 aa |
| Specificity | CD328 Polyclonal Antibody detects endogenous levels of CD328 protein. |
Additional Info
| Post Translational Modifications | Tyrosine phosphorylated. |
| Function | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). |
| Protein Name | Sialic Acid-Binding Ig-Like Lectin 7Siglec-7Adhesion Inhibitory Receptor Molecule 1Airm-1Cdw328D-SiglecQa79 Membrane ProteinP75Cd Antigen Cd328 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Sialic Acid-Binding Ig-Like Lectin 7 antibodyAnti-Siglec-7 antibodyAnti-Adhesion Inhibitory Receptor Molecule 1 antibodyAnti-Airm-1 antibodyAnti-Cdw328 antibodyAnti-D-Siglec antibodyAnti-Qa79 Membrane Protein antibodyAnti-P75 antibodyAnti-Cd Antigen Cd328 antibodyAnti-SIGLEC7 antibodyAnti-AIRM1 antibody |
Information sourced from Uniprot.org