| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SIGLEC6 |
| Gene ID: | 946 |
| Uniprot ID: | SIGL6_HUMAN |
| Immunogen Region: | 27-220 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 27-220 of human SIGLEC6 (NP_942142.3). |
| Immunogen Sequence: | QERRFQLEGPESLTVQEGLC VLVPCRLPTTLPASYYGYGY WFLEGADVPVATNDPDEEVQ EETRGRFHLLWDPRRKNCSL SIRDARRRDNAAYFFRLKSK WMKYGYTSSKLSVRVMALTH RPNISIPGTLESGHPSNLTC SVPWVCEQGTPPIFSWMSAA PTSLGPRTTQSSVLTITPRP QDHSTNLTCQVTFP |
| Tissue Specificity | Expressed at high levels in placenta (cyto- and syncytiotrophoblastic cells) and at lower levels in spleen, peripheral blood leukocytes (predominantly B-cells) and small intestine. |
| Function | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. |
| Protein Name | Sialic Acid-Binding Ig-Like Lectin 6 Siglec-6 Cd33 Antigen-Like 1 Cdw327 Obesity-Binding Protein 1 Ob-Bp1 Cd Antigen Cd327 |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Secreted |
| Alternative Antibody Names | Anti-Sialic Acid-Binding Ig-Like Lectin 6 antibody Anti-Siglec-6 antibody Anti-Cd33 Antigen-Like 1 antibody Anti-Cdw327 antibody Anti-Obesity-Binding Protein 1 antibody Anti-Ob-Bp1 antibody Anti-Cd Antigen Cd327 antibody Anti-SIGLEC6 antibody Anti-CD33L antibody Anti-CD33L1 antibody Anti-OBBP1 antibody |
Information sourced from Uniprot.org