Anti-SIGLEC5 antibody (17-551) (STJ26591)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SIGLEC5 (17-551) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SIGLEC5 |
| Gene ID | 8778 |
| Uniprot ID | SIGL5_HUMAN |
| Immunogen Region | 17-551 |
| Immunogen Sequence | EKPVYELQVQKSVTVQEGLC VLVPCSFSYPWRSWYSSPPL YVYWFRDGEIPYYAEVVATN NPDRRVKPETQGRFRLLGDV QKKNCSLSIGDARMEDTGSY FFRVERGRDVKYSYQQNKLN LEVTALIEKPDIHFLEPLES GRPTRLSCSLPGSCEAGPPL TFSWTGNALSPLDPETTRSS ELTLTPRPEDHGTNLTCQMK RQGAQVTTERTVQLNVSYAP QTITIFRNGIALEILQNTS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 17-434 of human SIGLEC5 (NP_003821.1). |
Additional Info
| Tissue Specificity | Expressed by monocytic/myeloid lineage cells. Found at high levels in peripheral blood leukocytes, spleen, bone marrow and at lower levels in lymph node, lung, appendix, placenta, pancreas and thymus. Expressed by monocytes and neutrophils but absent from leukemic cell lines representing early stages of myelomonocytic differentiation. |
| Function | Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Binds equally to alpha-2,3-linked and alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. |
| Protein Name | Sialic Acid-Binding Ig-Like Lectin 5Siglec-5Cd33 Antigen-Like 2Obesity-Binding Protein 2Ob-Bp2Ob-Binding Protein 2Cd Antigen Cd170 |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-6798695 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Sialic Acid-Binding Ig-Like Lectin 5 antibodyAnti-Siglec-5 antibodyAnti-Cd33 Antigen-Like 2 antibodyAnti-Obesity-Binding Protein 2 antibodyAnti-Ob-Bp2 antibodyAnti-Ob-Binding Protein 2 antibodyAnti-Cd Antigen Cd170 antibodyAnti-SIGLEC5 antibodyAnti-CD33L2 antibodyAnti-OBBP2 antibody |
Information sourced from Uniprot.org