| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Siglec1 (20-138) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Siglec1 |
| Gene ID: |
20612 |
| Uniprot ID: |
SN_MOUSE |
| Immunogen Region: |
20-138 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-138 of mouse Siglec1 (NP_035556.3). |
| Immunogen Sequence: |
TWGVSSPKNVQGLSGSCLLI PCIFSYPADVPVSNGITAIW YYDYSGKRQVVIHSGDPKLV DKRFRGRAELMGNMDHKVCN LLLKDLKPEDSGTYNFRFEI SDSNRWLDVKGTTVTVTTD |
| Tissue Specificity | Detected in lymph node in the subcapsular sinus, interfollicular regions, and T and B-cell boundary (at protein level). Expressed by macrophages in various tissues. Highest expression in spleen and lymph node with lower amounts in lung, liver, bone marrow, heart and skin. No expression in thymus, kidney, brain or small intestine. |
| Function | Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Plays a crucial role in limiting bacterial dissemination by engaging sialylated bacteria to promote effective phagocytosis and antigen presentation for the adaptive immune response. Mediates the uptake of various enveloped viruses via sialic acid recognition and subsequently induces the formation of intracellular compartments filled with virions (VCCs). In turn, enhances macrophage-to-T-cell transmission of several viruses including murine leukemia virus. Acts as an endocytic receptor mediating clathrin dependent endocytosis. Preferentially binds to alpha-2,3-linked sialic acid. Binds to SPN/CD43 on T-cells. May play a role in hemopoiesis. Plays a role in the inhibition of antiviral innate immune by promoting TBK1 degradation via TYROBP and TRIM27-mediated ubiquitination. |
| Protein Name | SialoadhesinSheep Erythrocyte ReceptorSerSialic Acid-Binding Ig-Like Lectin 1Siglec-1Cd Antigen Cd169 |
| Database Links | Reactome: R-MMU-198933 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: SecretedIsoform 3: Secreted |
| Alternative Antibody Names | Anti-Sialoadhesin antibodyAnti-Sheep Erythrocyte Receptor antibodyAnti-Ser antibodyAnti-Sialic Acid-Binding Ig-Like Lectin 1 antibodyAnti-Siglec-1 antibodyAnti-Cd Antigen Cd169 antibodyAnti-Siglec1 antibodyAnti-Sa antibodyAnti-Sn antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
