Anti-SIDT2 antibody (393-443 aa) (STJ195702)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human SIDT2 at the amino acid range 393-443
General Information
| Short Description | Rabbit polyclonal anti-SID1 transmembrane family member 2 (393-443 aa) for use in WB, ELISA and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SIDT2 |
| Gene ID | 51092 |
| Uniprot ID | SIDT2_HUMAN |
| Immunogen | Synthesized peptide derived from the human SIDT2 at the amino acid range 393-443 |
| Immunogen Region | 393-443 aa |
| Specificity | This antibody detects endogenous levels of SIDT2 at Human/Mouse/Rat |
Additional Info
| Function | Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded. Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis. In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp. |
| Protein Name | Sid1 Transmembrane Family Member 2 |
| Database Links | |
| Cellular Localisation | Lysosome MembraneMulti-Pass Membrane ProteinCell MembraneMainly Localizes To Lysosomes And Only Partly To The Plasma MembraneLysosomal Localization Is Required For Sidt2-Mediated Intracellular Degradation Of Endogenous Rna |
| Alternative Antibody Names | Anti-Sid1 Transmembrane Family Member 2 antibodyAnti-SIDT2 antibodyAnti-CGI-40 antibodyAnti-PSEC0072 antibodyAnti-UNQ685 antibodyAnti-PRO1325 antibody |
Information sourced from Uniprot.org