| Host: |
Rabbit |
| Applications: |
WB/ELISA/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SID1 transmembrane family member 2 (393-443 aa) is suitable for use in Western Blot, ELISA and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SIDT2 |
| Gene ID: |
51092 |
| Uniprot ID: |
SIDT2_HUMAN |
| Immunogen Region: |
393-443 aa |
| Specificity: |
This antibody detects endogenous levels of SIDT2 at Human/Mouse/Rat |
| Immunogen: |
Synthesized peptide derived from the human SIDT2 at the amino acid range 393-443 |
| Function | Mediates the translocation of RNA and DNA across the lysosomal membrane during RNA and DNA autophagy (RDA), a process in which RNA or DNA is directly imported into lysosomes in an ATP-dependent manner, and degraded. Involved in the uptake of single-stranded oligonucleotides by living cells, a process called gymnosis. In vitro, mediates the uptake of linear DNA more efficiently than that of circular DNA, but exhibits similar uptake efficacy toward RNA and DNA. Binds long double-stranded RNA (dsRNA) (500 - 700 base pairs), but not dsRNA shorter than 100 bp. |
| Protein Name | Sid1 Transmembrane Family Member 2 |
| Cellular Localisation | Lysosome MembraneMulti-Pass Membrane ProteinCell MembraneMainly Localizes To Lysosomes And Only Partly To The Plasma MembraneLysosomal Localization Is Required For Sidt2-Mediated Intracellular Degradation Of Endogenous Rna |
| Alternative Antibody Names | Anti-Sid1 Transmembrane Family Member 2 antibodyAnti-SIDT2 antibodyAnti-CGI-40 antibodyAnti-PSEC0072 antibodyAnti-UNQ685 antibodyAnti-PRO1325 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
