Anti-Shprh antibody (Internal Region) (STJA0005758)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide corresponding to amino acids from an internal region of mouse SHPRH protein
General Information
| Short Description | Rabbit polyclonal anti-SHPRH (Internal Region) for use in WB in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Antigen Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | PBS + 0.02% NaN3 |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | Shprh |
| Gene ID | 268281 |
| Uniprot ID | SHPRH_MOUSE |
| Immunogen | Synthetic peptide corresponding to amino acids from an internal region of mouse SHPRH protein |
| Immunogen Region | Internal Region |
| Specificity | Reacts with an internal region of the mouse SHPRH protein. 95% sequence identity to rat. 90% sequence identity to human |
Additional Info
| Function | E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. |
| Protein Name | E3 Ubiquitin-Protein Ligase ShprhRing-Type E3 Ubiquitin Transferase ShprhSnf2 - Histone-Linker - Phd And Ring Finger Domain-Containing Helicase |
| Database Links | Reactome: R-MMU-8866654 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Shprh antibodyAnti-Ring-Type E3 Ubiquitin Transferase Shprh antibodyAnti-Snf2 - Histone-Linker - Phd And Ring Finger Domain-Containing Helicase antibodyAnti-Shprh antibody |
Information sourced from Uniprot.org