| Short Description : | Rabbit polyclonal anti-E3 ubiquitin-protein ligase SHPRH (9-59 aa) for use in WB, IF, ELISA and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/IF/ELISA/IHC |
| Host: | Rabbit |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000IF ICC 1:50-200ELISA 1:2000-20000IHC-P 1:50-200 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SHPRH |
| Gene ID: | 257218 |
| Uniprot ID: | SHPRH_HUMAN |
| Immunogen: | Synthesized peptide derived from the human SHPRH at the amino acid range 9-59 |
| Immunogen Region: | 9-59 aa |
| Specificity: | This antibody detects endogenous levels of SHPRH at Human/Mouse |
| Function | E3 ubiquitin-protein ligase involved in DNA repair. Upon genotoxic stress, accepts ubiquitin from the UBE2N-UBE2V2 E2 complex and transfers it to 'Lys-164' of PCNA which had been monoubiquitinated by UBE2A/B-RAD18, promoting the formation of non-canonical poly-ubiquitin chains linked through 'Lys-63'. |
| Protein Name | E3 Ubiquitin-Protein Ligase ShprhRing-Type E3 Ubiquitin Transferase ShprhSnf2 - Histone-Linker - Phd And Ring Finger Domain-Containing Helicase |
| Database Links | Reactome: R-HSA-8866654 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Shprh antibodyAnti-Ring-Type E3 Ubiquitin Transferase Shprh antibodyAnti-Snf2 - Histone-Linker - Phd And Ring Finger Domain-Containing Helicase antibodyAnti-SHPRH antibodyAnti-KIAA2023 antibody |
Information sourced from Uniprot.org
