Anti-SHANK3 antibody (1600-1650) (STJ502996)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide taken within amino acid region 1600-1650 on mouse SH3 and multiple ankyrin repeat domains protein 3.
General Information
| Short Description | Rabbit polyclonal antibody anti-SHANK3 (1600-1650) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications. |
| Applications | ELISA/IHC/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 ยตg/ยตl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500ELISA: 1:10, 000IP: 1:150IHC: 1:50-1:100 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20ยฐC for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | Shank3 |
| Gene ID | 58234 |
| Uniprot ID | SHAN3_MOUSE |
| Immunogen | Synthetic peptide taken within amino acid region 1600-1650 on mouse SH3 and multiple ankyrin repeat domains protein 3. |
| Immunogen Region | 1600-1650 |
Additional Info
| Tissue Specificity | In brain, highly expressed in striatum, thalamus, hippocampus and granule cells of the cerebellum. |
| Function | Major scaffold postsynaptic density protein which interacts with multiple proteins and complexes to orchestrate the dendritic spine and synapse formation, maturation and maintenance. Interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and HOMER, respectively, and the actin-based cytoskeleton. Plays a role in the structural and functional organization of the dendritic spine and synaptic junction through the interaction with Arp2/3 and WAVE1 complex as well as the promotion of the F-actin clusters. By way of this control of actin dynamics, participates in the regulation of developing neurons growth cone motility and the NMDA receptor-signaling. Also modulates GRIA1 exocytosis and GRM5/MGLUR5 expression and signaling to control the AMPA and metabotropic glutamate receptor-mediated synaptic transmission and plasticity. May be required at an early stage of synapse formation and be inhibited by IGF1 to promote synapse maturation. |
| Protein Name | Sh3 And Multiple Ankyrin Repeat Domains Protein 3Shank3Proline-Rich Synapse-Associated Protein 2Prosap2Spank-2 |
| Database Links | Reactome: R-MMU-6794361Reactome: -MMU-8853659 |
| Cellular Localisation | CytoplasmSynapsePostsynaptic DensityCell ProjectionDendritic SpineIn Neuronal CellsExtends Into The Region Subjacent To The Postsynaptic Density (Psd) |
| Alternative Antibody Names | Anti-Sh3 And Multiple Ankyrin Repeat Domains Protein 3 antibodyAnti-Shank3 antibodyAnti-Proline-Rich Synapse-Associated Protein 2 antibodyAnti-Prosap2 antibodyAnti-Spank-2 antibodyAnti-Shank3 antibodyAnti-Kiaa1650 antibodyAnti-Prosap2 antibody |
Information sourced from Uniprot.org