• Western blot analysis of lysates from RAW264.7, Jurkat, HepG2, and COLO cells, using SHANK2 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of the lysates from HT-29 cells using SHANK2 antibody.
  • Western blot analysis of RAW264.7 cells using Shank 2 Polyclonal Antibody

Anti-SHANK2 antibody (331-380 aa) (STJ95648)

SKU:
STJ95648

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-SH3 and multiple ankyrin repeat domains protein 2 (331-380 aa) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC-P 1:50-300
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SHANK2
Gene ID: 22941
Uniprot ID: SHAN2_HUMAN
Immunogen Region: 331-380 aa
Specificity: Shank 2 Polyclonal Antibody detects endogenous levels of Shank 2 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human SHANK2 at the amino acid range 331-380
Function Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.
Protein Name Sh3 And Multiple Ankyrin Repeat Domains Protein 2
Shank2
Cortactin-Binding Protein 1
Cortbp1
Proline-Rich Synapse-Associated Protein 1
Database Links Reactome: R-HSA-6794361
Cellular Localisation Apical Cell Membrane
Cytoplasm
Synapse
Postsynaptic Density
Cell Projection
Growth Cone
Dendritic Spine
Colocalizes With Cortactin In Growth Cones In Differentiating Hippocampal Neurons
Colocalized With Pde4d To The Apical Membrane Of Colonic Crypt Cells
Alternative Antibody Names Anti-Sh3 And Multiple Ankyrin Repeat Domains Protein 2 antibody
Anti-Shank2 antibody
Anti-Cortactin-Binding Protein 1 antibody
Anti-Cortbp1 antibody
Anti-Proline-Rich Synapse-Associated Protein 1 antibody
Anti-SHANK2 antibody
Anti-CORTBP1 antibody
Anti-KIAA1022 antibody
Anti-PROSAP1 antibody

Information sourced from Uniprot.org

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