Host: |
Rabbit |
Applications: |
WB/IHC |
Reactivity: |
Human/Rat/Mouse |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-SH3 and multiple ankyrin repeat domains protein 2 (331-380 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: |
1 mg/mL |
Dilution Range: |
WB 1:500-2000IHC-P 1:50-300 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
SHANK2 |
Gene ID: |
22941 |
Uniprot ID: |
SHAN2_HUMAN |
Immunogen Region: |
331-380 aa |
Specificity: |
Shank 2 Polyclonal Antibody detects endogenous levels of Shank 2 protein. |
Immunogen: |
The antiserum was produced against synthesized peptide derived from the human SHANK2 at the amino acid range 331-380 |
Function | Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction. |
Protein Name | Sh3 And Multiple Ankyrin Repeat Domains Protein 2Shank2Cortactin-Binding Protein 1Cortbp1Proline-Rich Synapse-Associated Protein 1 |
Database Links | Reactome: R-HSA-6794361 |
Cellular Localisation | Apical Cell MembraneCytoplasmSynapsePostsynaptic DensityCell ProjectionGrowth ConeDendritic SpineColocalizes With Cortactin In Growth Cones In Differentiating Hippocampal NeuronsColocalized With Pde4d To The Apical Membrane Of Colonic Crypt Cells |
Alternative Antibody Names | Anti-Sh3 And Multiple Ankyrin Repeat Domains Protein 2 antibodyAnti-Shank2 antibodyAnti-Cortactin-Binding Protein 1 antibodyAnti-Cortbp1 antibodyAnti-Proline-Rich Synapse-Associated Protein 1 antibodyAnti-SHANK2 antibodyAnti-CORTBP1 antibodyAnti-KIAA1022 antibodyAnti-PROSAP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance