Anti-SH2D1A antibody (STJ191397)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-SH2 domain-containing protein 1A for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SH2D1A |
| Gene ID | 4068 |
| Uniprot ID | SH21A_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | SH21A Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. Initially it has been proposed that association with SLAMF1 prevents SLAMF1 binding to inhibitory effectors including INPP5D/SHIP1 and PTPN11/SHP-2. However, by simultaneous interactions, recruits FYN which subsequently phosphorylates and activates SLAMF1. Positively regulates CD244/2B4- and CD84-mediated natural killer (NK) cell functions. Can also promote CD48-, SLAMF6 -, LY9-, and SLAMF7-mediated NK cell activation. In the context of NK cell-mediated cytotoxicity enhances conjugate formation with target cells. May also regulate the activity of the neurotrophin receptors NTRK1, NTRK2 and NTRK3. |
| Protein Name | Sh2 Domain-Containing Protein 1aDuncan Disease Sh2-ProteinSignaling Lymphocytic Activation Molecule-Associated ProteinSlam-Associated ProteinT-Cell Signal Transduction Molecule Sap |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Sh2 Domain-Containing Protein 1a antibodyAnti-Duncan Disease Sh2-Protein antibodyAnti-Signaling Lymphocytic Activation Molecule-Associated Protein antibodyAnti-Slam-Associated Protein antibodyAnti-T-Cell Signal Transduction Molecule Sap antibodyAnti-SH2D1A antibodyAnti-DSHP antibodyAnti-SAP antibody |
Information sourced from Uniprot.org