Anti-SH2B2 antibody (Internal) (STJ91650)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the Internal region of human APS.
General Information
| Short Description | Rabbit polyclonal anti-SH2B adapter protein 2 (Internal) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SH2B2 |
| Gene ID | 10603 |
| Uniprot ID | SH2B2_HUMAN |
| Immunogen | Synthesized peptide derived from the Internal region of human APS. |
| Immunogen Region | Internal |
| Specificity | APS Polyclonal Antibody detects endogenous levels of APS protein. |
Additional Info
| Post Translational Modifications | Tyrosine phosphorylated by JAK2, KIT and other kinases activated by B-cell receptor in response to stimulation with cytokines, IL3, IL5, PDGF, IGF1, IGF2, CSF2/GM-CSF and cross-linking of the B-cell receptor complex. |
| Function | Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways. May be involved in coupling from immunoreceptor to Ras signaling. Acts as a negative regulator of cytokine signaling in collaboration with CBL. Binds to EPOR and suppresses EPO-induced STAT5 activation, possibly through a masking effect on STAT5 docking sites in EPOR. Suppresses PDGF-induced mitogenesis. May induce cytoskeletal reorganization via interaction with VAV3. |
| Protein Name | Sh2b Adapter Protein 2Adapter Protein With Pleckstrin Homology And Src Homology 2 DomainsSh2 And Ph Domain-Containing Adapter Protein Aps |
| Database Links | Reactome: R-HSA-1433559Reactome: R-HSA-983231 |
| Cellular Localisation | CytoplasmCell MembraneCytoplasmic Before Pdgf StimulationAfter Pdgf StimulationLocalized At The Cell Membrane And Peripheral Region |
| Alternative Antibody Names | Anti-Sh2b Adapter Protein 2 antibodyAnti-Adapter Protein With Pleckstrin Homology And Src Homology 2 Domains antibodyAnti-Sh2 And Ph Domain-Containing Adapter Protein Aps antibodyAnti-SH2B2 antibodyAnti-APS antibody |
Information sourced from Uniprot.org