• STJ73523 (1ug/ml) staining of PD19 (A) and (2µg/ml) K562 (B) cell lysate (35µg protein in RIPA buffer). Detected by chemiluminescence.

Anti-Sgta-Mouse antibody (84-97) (STJ73523)

SKU:
STJ73523-100

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Host: Goat
Applications: Pep-ELISA/WB/IHC
Reactivity: Human/Mouse/Rat/Dog/Pig/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-Sgta-Mouse (84-97) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-1-2µg/ml
IHC-5µg/ml
ELISA-antibody detection limit dilution 1:2000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: SGTA
Gene ID: 6449
Uniprot ID: SGTA_HUMAN
Immunogen Region: 84-97
Accession Number: NP_078775.1
Immunogen Sequence: PSEEDSAEAERLKT
Function Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states. Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex. Binds directly to HSC70 and HSP70 and regulates their ATPase activity. (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70.
Protein Name Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha
Alpha-Sgt
Vpu-Binding Protein
Ubp
Database Links Reactome: R-HSA-9609523
Cellular Localisation Cytoplasm
Nucleus
Co-Localizes With Hsp90ab1 In The Cytoplasm
Increased Nuclear Accumulation Seen During Cell Apoptosis
Alternative Antibody Names Anti-Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha antibody
Anti-Alpha-Sgt antibody
Anti-Vpu-Binding Protein antibody
Anti-Ubp antibody
Anti-SGTA antibody
Anti-SGT antibody
Anti-SGT1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance