Anti-SGTA antibody (1-120) (STJ29445)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SGTA (1-120) antibody for use in WB, IF, ICC and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SGTA |
| Gene ID | 6449 |
| Uniprot ID | SGTA_HUMAN |
| Immunogen Region | 1-120 |
| Immunogen Sequence | MDNKKRLAYAIIQFLHDQLR HGGLSSDAQESLEVAIQCLE TAFGVTVEDSDLALPQTLPE IFEAAATGKEMPQDLRSPAR TPPSEEDSAEAERLKTEGNE QMKVENFEAAVHFYGKAIEL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-120 of human SGTA (NP_003012.1). |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Function | Co-chaperone that binds misfolded and hydrophobic patches-containing client proteins in the cytosol. Mediates their targeting to the endoplasmic reticulum but also regulates their sorting to the proteasome when targeting fails. Functions in tail-anchored/type II transmembrane proteins membrane insertion constituting with ASNA1 and the BAG6 complex a targeting module. Functions upstream of the BAG6 complex and ASNA1, binding more rapidly the transmembrane domain of newly synthesized proteins. It is also involved in the regulation of the endoplasmic reticulum-associated misfolded protein catabolic process via its interaction with BAG6: collaborates with the BAG6 complex to maintain hydrophobic substrates in non-ubiquitinated states. Competes with RNF126 for interaction with BAG6, preventing the ubiquitination of client proteins associated with the BAG6 complex. Binds directly to HSC70 and HSP70 and regulates their ATPase activity. (Microbial infection) In case of infection by polyomavirus, involved in the virus endoplasmic reticulum membrane penetration and infection via interaction with DNAJB12, DNAJB14 and HSPA8/Hsc70. |
| Protein Name | Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein AlphaAlpha-SgtVpu-Binding ProteinUbp |
| Database Links | Reactome: R-HSA-9609523 |
| Cellular Localisation | CytoplasmNucleusCo-Localizes With Hsp90ab1 In The CytoplasmIncreased Nuclear Accumulation Seen During Cell Apoptosis |
| Alternative Antibody Names | Anti-Small Glutamine-Rich Tetratricopeptide Repeat-Containing Protein Alpha antibodyAnti-Alpha-Sgt antibodyAnti-Vpu-Binding Protein antibodyAnti-Ubp antibodyAnti-SGTA antibodyAnti-SGT antibodyAnti-SGT1 antibody |
Information sourced from Uniprot.org