Anti-SFTPD antibody [S4904RM] (STJ11104904)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Pulmonary Surfactant-Associated Protein D antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S4904RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:2000-1:20000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SFTPD |
| Gene ID | 6441 |
| Uniprot ID | SFTPD_HUMAN |
| Immunogen Sequence | MLLFLLSALVLLTQPLGYLE AEMKTYSHRTMPSACTLVMC SSVESGLPGRDGRDGREGPR GEKGDPGLPGAAGQAGMPGQ AGPVGPKGDNGSVGEPGPKG DTGPSGPPGPPGVPGPAGRE GPLGKQGNIGPQGKPGPKGE AGPKGEVGAPGMQGSAGARG LAGPKGERGVPGERGVPGNT GAAGSAGAMGPQGSPGARGP PGLKGDKGIPGDKGAKGESG LPDVASLRQQVEALQGQVQ |
| Specificity | A synthesized peptide derived from human Surfactant protein D/SP-D. |
Additional Info
| Tissue Specificity | Expressed in lung, brain, pancreas and adipose tissue (mainly mature adipocytes). |
| Post Translational Modifications | The N-terminus is blocked. Hydroxylation on proline residues within the sequence motif, GXPG, is most likely to be 4-hydroxy as this fits the requirement for 4-hydroxylation in vertebrates. S-nitrosylation at Cys-35 and Cys-40 alters the quaternary structure which results in a pro-inflammatory chemoattractive signaling activity with macrophages. |
| Function | Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha-glucosyl moieties. |
| Protein Name | Pulmonary Surfactant-Associated Protein DPsp-DSp-DCollectin-7Lung Surfactant Protein D |
| Database Links | Reactome: R-HSA-166016Reactome: R-HSA-168179Reactome: R-HSA-198933Reactome: R-HSA-391160Reactome: R-HSA-5683826Reactome: R-HSA-5686938Reactome: R-HSA-5688849Reactome: R-HSA-5688890Reactome: R-HSA-9692916Reactome: R-HSA-9705671 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixSurface Film |
| Alternative Antibody Names | Anti-Pulmonary Surfactant-Associated Protein D antibodyAnti-Psp-D antibodyAnti-Sp-D antibodyAnti-Collectin-7 antibodyAnti-Lung Surfactant Protein D antibodyAnti-SFTPD antibodyAnti-COLEC7 antibodyAnti-PSPD antibodyAnti-SFTP4 antibody |
Information sourced from Uniprot.org