Anti-SFRP1 antibody [R06-4C7] (STJA0036397)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human SFRP1
General Information
| Short Description | Rabbit monoclonal anti-SFRP1 for use in WB, IHC-P, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R06-4C7 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | SFRP1 |
| Gene ID | 6422 |
| Uniprot ID | SFRP1_HUMAN |
| Immunogen | A synthesized peptide derived from human SFRP1 |
Additional Info
| Tissue Specificity | Widely expressed. Absent from lung, liver and peripheral blood leukocytes. Highest levels in heart and fetal kidney. Also expressed in testis, ovary, fetal brain and lung, leiomyomal cells, myometrial cells and vascular smooth muscle cells. Expressed in foreskin fibroblasts and in keratinocytes. |
| Function | Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP1 decreases intracellular beta-catenin levels. Has antiproliferative effects on vascular cells, in vitro and in vivo, and can induce, in vivo, an angiogenic response. In vascular cell cycle, delays the G1 phase and entry into the S phase. In kidney development, inhibits tubule formation and bud growth in metanephroi. Inhibits WNT1/WNT4-mediated TCF-dependent transcription. |
| Protein Name | Secreted Frizzled-Related Protein 1Frp-1Sfrp-1Secreted Apoptosis-Related Protein 2Sarp-2 |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-3772470 |
| Cellular Localisation | SecretedCell Membrane Or Extracellular Matrix-AssociatedReleased By Heparin-Binding |
| Alternative Antibody Names | Anti-Secreted Frizzled-Related Protein 1 antibodyAnti-Frp-1 antibodyAnti-Sfrp-1 antibodyAnti-Secreted Apoptosis-Related Protein 2 antibodyAnti-Sarp-2 antibodyAnti-SFRP1 antibodyAnti-FRP antibodyAnti-FRP1 antibodyAnti-SARP2 antibody |
Information sourced from Uniprot.org