Anti-SF3A1 antibody (715-785) (STJ11100905)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SF3A1 (715-785) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:1000-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SF3A1 |
| Gene ID | 10291 |
| Uniprot ID | SF3A1_HUMAN |
| Immunogen Region | 715-785 |
| Immunogen Sequence | QDKTEWKLNGQVLVFTLPLT DQVSVIKVKIHEATGMPAGK QKLQYEGIFIKDSNSLAYYN MANGAVIHLAL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 715-785 of human SF3A1 (Q15459). |
Additional Info
| Tissue Specificity | Ubiquitously expressed. |
| Function | Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs. The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing. Within the 17S U2 SnRNP complex, SF3A1 is part of the SF3A subcomplex that contributes to the assembly of the 17S U2 snRNP, and the subsequent assembly of the pre-spliceosome 'E' complex and the pre-catalytic spliceosome 'A' complex. Involved in pre-mRNA splicing as a component of pre-catalytic spliceosome 'B' complexes. |
| Protein Name | Splicing Factor 3a Subunit 1Sf3a120Spliceosome-Associated Protein 114Sap 114 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | NucleusNucleus Speckle |
| Alternative Antibody Names | Anti-Splicing Factor 3a Subunit 1 antibodyAnti-Sf3a120 antibodyAnti-Spliceosome-Associated Protein 114 antibodyAnti-Sap 114 antibodyAnti-SF3A1 antibodyAnti-SAP114 antibody |
Information sourced from Uniprot.org