| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SF1 |
| Gene ID: | 7536 |
| Uniprot ID: | SF01_HUMAN |
| Immunogen Region: | 1-280 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human SF1 (NP_973727.1). |
| Immunogen Sequence: | MATGANATPLDFPSKKRKRS RWNQDTMEQKTVIPGMPTVI PPGLTREQERAYIVQLQIED LTRKLRTGDLGIPPNPEDRS PSPEPIYNSEGKRLNTREFR TRKKLEEERHNLITEMVALN PDFKPPADYKPPATRVSDKV MIPQDEYPEINFVGLLIGPR GNTLKNIEKECNAKIMIRGK GSVKEGKVGRKDGQMLPGED EPLHALVTANTMENVKKAVE QIRNILKQGIETPEDQNDL |
| Tissue Specificity | Detected in lung, ovary, adrenal gland, colon, kidney, muscle, pancreas, thyroid, placenta, brain, liver and heart. |
| Post Translational Modifications | Phosphorylation on Ser-20 interferes with U2AF2 binding and spliceosome assembly. Isoform 6 is phosphorylated on Ser-463. |
| Function | Necessary for the ATP-dependent first step of spliceosome assembly. Binds to the intron branch point sequence (BPS) 5'-UACUAAC-3' of the pre-mRNA. May act as transcription repressor. |
| Protein Name | Splicing Factor 1Mammalian Branch Point-Binding ProteinBbpMbbpTranscription Factor Zfm1Zinc Finger Gene In Men1 LocusZinc Finger Protein 162 |
| Database Links | Reactome: R-HSA-72163 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Splicing Factor 1 antibodyAnti-Mammalian Branch Point-Binding Protein antibodyAnti-Bbp antibodyAnti-Mbbp antibodyAnti-Transcription Factor Zfm1 antibodyAnti-Zinc Finger Gene In Men1 Locus antibodyAnti-Zinc Finger Protein 162 antibodyAnti-SF1 antibodyAnti-ZFM1 antibodyAnti-ZNF162 antibody |
Information sourced from Uniprot.org