Anti-SETDB2 antibody (148-378) (STJ29528)

Name: Anti-SETDB2 antibody (148-378) (STJ29528)
SKU: STJ29528
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ29528

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Short Description	Rabbit polyclonal SETDB2 (148-378) antibody for use in WB and ELISA in mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	SETDB2
Gene ID	83852
Uniprot ID	SETB2_HUMAN
Immunogen Region	148-378
Immunogen Sequence	SGACLMKMPLNLKGENPLQL PIKCHFQRRHAKTNSHSSAL HVSYKTPCGRSLRNVEEVFR YLLETECNFLFTDNFSFNTY VQLARNYPKQKEVVSDVDIS NGVESVPISFCNEIDSRKLP QFKYRKTVWPRAYNLTNFSS MFTDSCDCSEGCIDITKCAC LQLTARNAKTSPLSSDKITT GYKYKRLQRQIPTGIYECSL LCKCNRQLCQNRVVQHGPQV RLQVFKTEQKG
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 148-378 of human SETDB2 (NP_114121.2).

Tissue Specificity	Ubiquitous. Highest expression in heart, testis and ovary.
Function	Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere-associated repeats. Plays a role in chromosome condensation and segregation during mitosis.
Protein Name	Histone-Lysine N-Methyltransferase Setdb2 Chronic Lymphocytic Leukemia Deletion Region Gene 8 Protein Lysine N-Methyltransferase 1f Set Domain Bifurcated 2
Database Links	Reactome: R-HSA-3214841
Cellular Localisation	Nucleus Chromosome
Alternative Antibody Names	Anti-Histone-Lysine N-Methyltransferase Setdb2 antibody Anti-Chronic Lymphocytic Leukemia Deletion Region Gene 8 Protein antibody Anti-Lysine N-Methyltransferase 1f antibody Anti-Set Domain Bifurcated 2 antibody Anti-SETDB2 antibody Anti-C13orf4 antibody Anti-CLLD8 antibody Anti-KMT1F antibody

Information sourced from Uniprot.org