Anti-SETD7 antibody (STJA0007384)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SETD7
General Information
| Short Description | Rabbit polyclonal anti-Histone-lysine N-methyltransferase SETD7 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SETD7 |
| Gene ID | 80854 |
| Uniprot ID | SETD7_HUMAN |
| Immunogen | Synthesized peptide derived from human SETD7 |
| Specificity | This antibody detects endogenous levels of SETD7 at Human, Mouse |
Additional Info
| Function | Histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Plays a central role in the transcriptional activation of genes such as collagenase or insulin. Recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. Also has methyltransferase activity toward non-histone proteins such as CGAS, p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the KR-STA-K in substrate proteins. Monomethylates 'Lys-189' of TAF10, leading to increase the affinity of TAF10 for RNA polymerase II. Monomethylates 'Lys-372' of p53/TP53, stabilizing p53/TP53 and increasing p53/TP53-mediated transcriptional activation. Monomethylates 'Lys-491' of CGAS, promoting interaction between SGF29 and CGAS. |
| Protein Name | Histone-Lysine N-Methyltransferase Setd7Histone H3-K4 Methyltransferase Setd7H3-K4-Hmtase Setd7Lysine N-Methyltransferase 7Set Domain-Containing Protein 7Set7/9 |
| Database Links | Reactome: R-HSA-3214841 |
| Cellular Localisation | NucleusChromosome |
| Alternative Antibody Names | Anti-Histone-Lysine N-Methyltransferase Setd7 antibodyAnti-Histone H3-K4 Methyltransferase Setd7 antibodyAnti-H3-K4-Hmtase Setd7 antibodyAnti-Lysine N-Methyltransferase 7 antibodyAnti-Set Domain-Containing Protein 7 antibodyAnti-Set7/9 antibodyAnti-SETD7 antibodyAnti-KIAA1717 antibodyAnti-KMT7 antibodyAnti-SET7 antibodyAnti-SET9 antibody |
Information sourced from Uniprot.org