| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SETD6 |
| Gene ID: | 79918 |
| Uniprot ID: | SETD6_HUMAN |
| Immunogen Region: | 301-473 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 301-473 of human SETD6 (NP_001153777.1). |
| Immunogen Sequence: | EPYPDNTDDTADIQMVTVRE AALQGTKTEAERHLVYERWD FLCKLEMVGEEGAFVIGREE VLTEEELTTTLKVLCMPAEE FRELKDQDGGGDDKREEGSL TITNIPKLKASWRQLLQNSV LLTLQTYATDLKTDQGLLSN KEVYAKLSWREQQALQVRYG QKMILHQLLELTS |
| Post Translational Modifications | Automethylated.Lys-39 and Lys-179 serve as the major automethylation sites. |
| Function | Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1). Required for the maintenance of embryonic stem cell self-renewal. Methylates PAK4. |
| Protein Name | N-Lysine Methyltransferase Setd6Set Domain-Containing Protein 6 |
| Database Links | Reactome: R-HSA-3214841 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-N-Lysine Methyltransferase Setd6 antibodyAnti-Set Domain-Containing Protein 6 antibodyAnti-SETD6 antibody |
Information sourced from Uniprot.org