| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SESN3 (1-310) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SESN3 |
| Gene ID: |
143686 |
| Uniprot ID: |
SESN3_HUMAN |
| Immunogen Region: |
1-310 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human SESN3 (NP_653266.2). |
| Immunogen Sequence: |
MNRGGGSPSAAANYLLCTNC RKVLRKDKRIRVSQPLTRGP SAFIPEKEVVQANTVDERTN FLVEEYSTSGRLDNITQVMS LHTQYLESFLRSQFYMLRMD GPLPLPYRHYIAIMAAARHQ CSYLINMHVDEFLKTGGIAE WLNGLEYVPQRLKNLNEINK LLAHRPWLITKEHIQKLVKT GENNWSLPELVHAVVLLAHY HALASFVFGSGINPERDPEI SNGFRLISVNNFCVCDLAN |
| Tissue Specificity | Widely expressed. |
| Function | May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway. May also regulate the insulin-receptor signaling pathway through activation of TORC2. This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. |
| Protein Name | Sestrin-3 |
| Database Links | Reactome: R-HSA-5628897 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Sestrin-3 antibodyAnti-SESN3 antibodyAnti-SEST3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
