Anti-SESN3 antibody (1-310) (STJ27143)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SESN3 (1-310) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SESN3 |
| Gene ID | 143686 |
| Uniprot ID | SESN3_HUMAN |
| Immunogen Region | 1-310 |
| Immunogen Sequence | MNRGGGSPSAAANYLLCTNC RKVLRKDKRIRVSQPLTRGP SAFIPEKEVVQANTVDERTN FLVEEYSTSGRLDNITQVMS LHTQYLESFLRSQFYMLRMD GPLPLPYRHYIAIMAAARHQ CSYLINMHVDEFLKTGGIAE WLNGLEYVPQRLKNLNEINK LLAHRPWLITKEHIQKLVKT GENNWSLPELVHAVVLLAHY HALASFVFGSGINPERDPEI SNGFRLISVNNFCVCDLAN |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-310 of human SESN3 (NP_653266.2). |
Additional Info
| Tissue Specificity | Widely expressed. |
| Function | May function as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway. May also regulate the insulin-receptor signaling pathway through activation of TORC2. This metabolic regulator may also play a role in protection against oxidative and genotoxic stresses. May prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. |
| Protein Name | Sestrin-3 |
| Database Links | Reactome: R-HSA-5628897 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Sestrin-3 antibodyAnti-SESN3 antibodyAnti-SEST3 antibody |
Information sourced from Uniprot.org