• Immunofluorescence analysis of HepG2 cells using SERPING1 Rabbit polyclonal antibody (STJ25490) at dilution of 1:20 (40x lens). Blue: DAPI for nuclear staining.
  • Immunofluorescence analysis of HeLa cells using SERPING1 Rabbit polyclonal antibody (STJ25490) at dilution of 1:20 (40x lens). Blue: DAPI for nuclear staining.
  • Western blot analysis of extracts of Human plasma, using SERPING1 antibody (STJ25490) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 30s.

Anti-SERPING1 antibody (201-500) (STJ25490)

SKU:
STJ25490

£169.50 - £449.50
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Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-C1 Inactivator (201-500) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SERPING1
Gene ID: 710
Uniprot ID: IC1_HUMAN
Immunogen Region: 201-500
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 201-500 of human SERPING1 (NP_001027466.1).
Immunogen Sequence: KDFTCVHQALKGFTTKGVTS VSQIFHSPDLAIRDTFVNAS RTLYSSSPRVLSNNSDANLE LINTWVAKNTNNKISRLLDS LPSDTRLVLLNAIYLSAKWK TTFDPKKTRMEPFHFKNSVI KVPMMNSKKYPVAHFIDQTL KAKVGQLQLSHNLSLVILVP QNLKHRLEDMEQALSPSVFK AIMEKLEMSKFQPTLLTLPR IKVTTSQDMLSIMEKLEFFD FSYDLNLCGLTEDPDLQVS
Post Translational Modifications Highly glycosylated (49%) with N- and O-glycosylation. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan heterogeneity at Asn-25: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor). Can be proteolytically cleaved by E.coli stcE.
Function Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.
Protein Name Plasma Protease C1 Inhibitor
C1 Inh
C1inh
C1 Esterase Inhibitor
C1-Inhibiting Factor
Serpin G1
Database Links Reactome: R-HSA-114608
Reactome: R-HSA-140837
Reactome: R-HSA-9657689
Reactome: R-HSA-977606
Cellular Localisation Secreted
Alternative Antibody Names Anti-Plasma Protease C1 Inhibitor antibody
Anti-C1 Inh antibody
Anti-C1inh antibody
Anti-C1 Esterase Inhibitor antibody
Anti-C1-Inhibiting Factor antibody
Anti-Serpin G1 antibody
Anti-SERPING1 antibody
Anti-C1IN antibody
Anti-C1NH antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance