Anti-SERPING1 antibody (201-500) (STJ25490)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal C1 Inactivator (201-500) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SERPING1 |
| Gene ID | 710 |
| Uniprot ID | IC1_HUMAN |
| Immunogen Region | 201-500 |
| Immunogen Sequence | KDFTCVHQALKGFTTKGVTS VSQIFHSPDLAIRDTFVNAS RTLYSSSPRVLSNNSDANLE LINTWVAKNTNNKISRLLDS LPSDTRLVLLNAIYLSAKWK TTFDPKKTRMEPFHFKNSVI KVPMMNSKKYPVAHFIDQTL KAKVGQLQLSHNLSLVILVP QNLKHRLEDMEQALSPSVFK AIMEKLEMSKFQPTLLTLPR IKVTTSQDMLSIMEKLEFFD FSYDLNLCGLTEDPDLQVS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 201-500 of human SERPING1 (NP_001027466.1). |
Additional Info
| Post Translational Modifications | Highly glycosylated (49%) with N- and O-glycosylation. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan heterogeneity at Asn-25: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor). Cleaved by C1S in vitro. (Microbial infection) Can be proteolytically cleaved by E.coli stcE. |
| Function | Serine protease inhibitor, which acrs as a regulator of the classical complement pathway. Forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May also regulate blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein. |
| Protein Name | Plasma Protease C1 InhibitorC1 InhC1inhC1 Esterase InhibitorC1-Inhibiting FactorSerpin G1 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-140837Reactome: R-HSA-9657689Reactome: R-HSA-977606 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Plasma Protease C1 Inhibitor antibodyAnti-C1 Inh antibodyAnti-C1inh antibodyAnti-C1 Esterase Inhibitor antibodyAnti-C1-Inhibiting Factor antibodyAnti-Serpin G1 antibodyAnti-SERPING1 antibodyAnti-C1IN antibodyAnti-C1NH antibody |
Information sourced from Uniprot.org