Anti-SERPING1 antibody [1F7] (STJA0032565)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenPurified C1 inhibitor from human blood
General Information
| Short Description | Mouse monoclonal anti-SERPING1 for use in ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 1F7 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | ELISA 1:10000 |
| Formulation | Liquid in PBS containing 0.09% sodium azide as a preservative. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | SERPING1 |
| Gene ID | 710 |
| Uniprot ID | IC1_HUMAN |
| Immunogen | Purified C1 inhibitor from human blood |
Additional Info
| Post Translational Modifications | Highly glycosylated (49%) with N- and O-glycosylation. O-glycosylated with core 1 or possibly core 8 glycans. N-glycan heterogeneity at Asn-25: Hex5HexNAc4 (minor), dHex1Hex5HexNAc4 (minor), Hex6HexNAc5 (major) and dHex1Hex6HexNAc5 (minor). Cleaved by C1S in vitro. (Microbial infection) Can be proteolytically cleaved by E.coli stcE. |
| Function | Serine protease inhibitor, which acrs as a regulator of the classical complement pathway. Forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May also regulate blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein. |
| Protein Name | Plasma Protease C1 InhibitorC1 InhC1inhC1 Esterase InhibitorC1-Inhibiting FactorSerpin G1 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-140837Reactome: R-HSA-9657689Reactome: R-HSA-977606 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Plasma Protease C1 Inhibitor antibodyAnti-C1 Inh antibodyAnti-C1inh antibodyAnti-C1 Esterase Inhibitor antibodyAnti-C1-Inhibiting Factor antibodyAnti-Serpin G1 antibodyAnti-SERPING1 antibodyAnti-C1IN antibodyAnti-C1NH antibody |
Information sourced from Uniprot.org