| Host: | Rabbit |
| Applications: | IHC/IF/WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Pigment epithelium-derived factor (258-307 aa) is suitable for use in Immunohistochemistry, Immunofluorescence, Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC-P 1:100-300 ELISA 1:20000 IF 1:100-300 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SERPINF1 |
| Gene ID: | 5176 |
| Uniprot ID: | PEDF_HUMAN |
| Immunogen Region: | 258-307 aa |
| Specificity: | PEDF Polyclonal Antibody detects endogenous levels of PEDF protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human PEDF at the amino acid range 258-307 |
| Post Translational Modifications | The N-terminus is blocked. Extracellular phosphorylation enhances antiangiogenic activity. N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan. |
| Function | Neurotrophic protein.induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity. |
| Protein Name | Pigment Epithelium-Derived Factor Pedf Cell Proliferation-Inducing Gene 35 Protein Epc-1 Serpin F1 |
| Cellular Localisation | Secreted Melanosome Enriched In Stage I Melanosomes |
| Alternative Antibody Names | Anti-Pigment Epithelium-Derived Factor antibody Anti-Pedf antibody Anti-Cell Proliferation-Inducing Gene 35 Protein antibody Anti-Epc-1 antibody Anti-Serpin F1 antibody Anti-SERPINF1 antibody Anti-PEDF antibody Anti-PIG35 antibody |
Information sourced from Uniprot.org