![Anti-SERPINE1/PAI-1 nanobody [SAA1079] (STJN000104)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200717/412899/STJN000104-SDS-PAGE-1__68482.1749232437.jpg?c=1 "Anti-SERPINE1/PAI-1 nanobody [SAA1079] (STJN000104)")
![Anti-SERPINE1/PAI-1 nanobody [SAA1079] (STJN000104)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200717/412899/STJN000104-SDS-PAGE-1__68482.1749232437.jpg?c=1 "Anti-SERPINE1/PAI-1 nanobody [SAA1079] (STJN000104)")
Anti-SERPINE1/PAI-1 nanobody [SAA1079] (STJN000104)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Plasminogen Activator Inhibitor 1 is suitable for use in ELISA research applications. |
| Applications | ELISA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1079 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | SERPINE1 |
| Gene ID | 5054 |
| Uniprot ID | PAI1_HUMAN |
Additional Info
| Post Translational Modifications | Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-|-Met-370 bond. |
| Function | Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence. Plays a role in alveolar type 2 cells senescence in the lung. Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis. |
| Protein Name | Plasminogen Activator Inhibitor 1PaiPai-1Endothelial Plasminogen Activator InhibitorSerpin E1 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-1368108Reactome: R-HSA-2173796Reactome: R-HSA-3000178Reactome: R-HSA-75205Reactome: R-HSA-9926550 |
| Cellular Localisation | Secreted |
| Alternative Nanobody Names | Anti-Plasminogen Activator Inhibitor 1 nanobodyAnti-Pai nanobodyAnti-Pai-1 nanobodyAnti-Endothelial Plasminogen Activator Inhibitor nanobodyAnti-Serpin E1 nanobodyAnti-SERPINE1 nanobodyAnti-PAI1 nanobodyAnti-PLANH1 nanobody |
Information sourced from Uniprot.org