Anti-SERPINE1/PAI-1 antibody [8H9D4] (STJA0019606)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Plasminogen Activator Inhibitor 1 antibody for use in ELISA, Neut and WB in human and pig samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/Neut/WB |
| Host | Mouse |
| Reactivity | Human/Pig |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 8H9D4 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | SERPINE1 |
| Gene ID | 5054 |
| Uniprot ID | PAI1_HUMAN |
Additional Info
| Post Translational Modifications | Inactivated by proteolytic attack of the urokinase-type (u-PA) and the tissue-type (TPA), cleaving the 369-Arg-|-Met-370 bond. |
| Function | Serine protease inhibitor. Inhibits TMPRSS7. Is a primary inhibitor of tissue-type plasminogen activator (PLAT) and urokinase-type plasminogen activator (PLAU). As PLAT inhibitor, it is required for fibrinolysis down-regulation and is responsible for the controlled degradation of blood clots. As PLAU inhibitor, it is involved in the regulation of cell adhesion and spreading. Acts as a regulator of cell migration, independently of its role as protease inhibitor. It is required for stimulation of keratinocyte migration during cutaneous injury repair. It is involved in cellular and replicative senescence. Plays a role in alveolar type 2 cells senescence in the lung. Is involved in the regulation of cementogenic differentiation of periodontal ligament stem cells, and regulates odontoblast differentiation and dentin formation during odontogenesis. |
| Protein Name | Plasminogen Activator Inhibitor 1PaiPai-1Endothelial Plasminogen Activator InhibitorSerpin E1 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-1368108Reactome: R-HSA-2173796Reactome: R-HSA-3000178Reactome: R-HSA-75205Reactome: R-HSA-9926550 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Plasminogen Activator Inhibitor 1 antibodyAnti-Pai antibodyAnti-Pai-1 antibodyAnti-Endothelial Plasminogen Activator Inhibitor antibodyAnti-Serpin E1 antibodyAnti-SERPINE1 antibodyAnti-PAI1 antibodyAnti-PLANH1 antibody |
Information sourced from Uniprot.org