• STJ73388 (0. 5µg/ml) staining of Human Placenta lysate (35µg protein in RIPA buffer) with (B) and without (A) blocking with the immunizing peptide. Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-SERPINB1 antibody (130-143) (STJ73388)

SKU:
STJ73388-100

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Host: Goat
Applications: Pep-ELISA/WB/IHC
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-SERPINB1 (130-143) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: IHC-5µg/ml
ELISA-antibody detection limit dilution 1:64000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: SERPINB1
Gene ID: 1992
Uniprot ID: ILEU_HUMAN
Immunogen Region: 130-143
Accession Number: NP_109591.1
Immunogen Sequence: KTINQWVKGQTEGK
Function Neutrophil serine protease inhibitor that plays an essential role in the regulation of the innate immune response, inflammation and cellular homeostasis. Acts primarily to protect the cell from proteases released in the cytoplasm during stress or infection. These proteases are important in killing microbes but when released from granules, these potent enzymes also destroy host proteins and contribute to mortality. Regulates the activity of the neutrophil proteases elastase, cathepsin G, proteinase-3, chymase, chymotrypsin, and kallikrein-3. Acts also as a potent intracellular inhibitor of GZMH by directly blocking its proteolytic activity. During inflammation, limits the activity of inflammatory caspases CASP1, CASP4 and CASP5 by suppressing their caspase-recruitment domain (CARD) oligomerization and enzymatic activation. When secreted, promotes the proliferation of beta-cells via its protease inhibitory function.
Protein Name Leukocyte Elastase Inhibitor
Lei
Monocyte/Neutrophil Elastase Inhibitor
Ei
M/Nei
Peptidase Inhibitor 2
Pi-2
Serpin B1
Database Links Reactome: R-HSA-6798695
Cellular Localisation Secreted
Cytoplasm
Cytolytic Granule
Early Endosome
Alternative Antibody Names Anti-Leukocyte Elastase Inhibitor antibody
Anti-Lei antibody
Anti-Monocyte/Neutrophil Elastase Inhibitor antibody
Anti-Ei antibody
Anti-M/Nei antibody
Anti-Peptidase Inhibitor 2 antibody
Anti-Pi-2 antibody
Anti-Serpin B1 antibody
Anti-SERPINB1 antibody
Anti-ELANH2 antibody
Anti-MNEI antibody
Anti-PI2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance