Anti-Serine Racemase antibody [R03-1G5] (STJA0035359)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide of human Serine racemase
General Information
| Short Description | Rabbit monoclonal anti-Serine Racemase for use in WB and IP in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IP |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R03-1G5 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IP 1:20 |
| Formulation | 50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | SRR |
| Gene ID | 63826 |
| Uniprot ID | SRR_HUMAN |
| Immunogen | A synthetic peptide of human Serine racemase |
Additional Info
| Tissue Specificity | Expressed in the cerebellum, hippocampus, dorsolateral prefrontal cortex, and in motor neurons and glial cells of the lumbar spinal cord (at protein level). Increased in the dorsolateral prefrontal cortex of schizophrenic patients (at protein level). Brain: expressed at high levels in hippocampus and corpus callosum, intermediate levels in substantia nigra and caudate, and low levels in amygdala, thalamus, and subthalamic nuclei. Expressed in heart, skeletal muscle, kidney, and liver. |
| Post Translational Modifications | S-nitrosylated, leading to decrease the enzyme activity. |
| Function | Catalyzes the synthesis of D-serine from L-serine. D-serine is a key coagonist with glutamate at NMDA receptors. Has dehydratase activity towards both L-serine and D-serine. |
| Protein Name | Serine RacemaseD-Serine Ammonia-LyaseD-Serine DehydrataseL-Serine Ammonia-LyaseL-Serine Dehydratase |
| Database Links | Reactome: R-HSA-977347 |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Serine Racemase antibodyAnti-D-Serine Ammonia-Lyase antibodyAnti-D-Serine Dehydratase antibodyAnti-L-Serine Ammonia-Lyase antibodyAnti-L-Serine Dehydratase antibodyAnti-SRR antibody |
Information sourced from Uniprot.org