Anti-SERBP1 antibody [4G2] (STJA0032638)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
ImmunogenPurified recombinant human SERBP1 protein fragments expressed in E.coli.
General Information
| Short Description | Mouse monoclonal anti-SERBP1 for use in WB and IHC-P in Human, Monkey, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P |
| Host | Mouse |
| Reactivity | Human/Monkey/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 4G2 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100 |
| Formulation | Liquid in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | SERBP1 |
| Gene ID | 26135 |
| Uniprot ID | SERB1_HUMAN |
| Immunogen | Purified recombinant human SERBP1 protein fragments expressed in E.coli. |
Additional Info
| Tissue Specificity | Expressed at high level in the heart, skeletal muscle and kidney, and at low levels in placenta, liver and brain. |
| Post Translational Modifications | Phosphorylation by MTOR inhibits SERBP1 and relieves ribosome hibernation. |
| Function | Ribosome-binding protein that promotes ribosome hibernation, a process during which ribosomes are stabilized in an inactive state and preserved from proteasomal degradation. Acts via its association with EEF2/eEF2 factor, sequestering EEF2/eEF2 at the A-site of the ribosome and promoting ribosome stabilization and storage in an inactive state. May also play a role in the regulation of mRNA stability: binds to the 3'-most 134 nt of the SERPINE1/PAI1 mRNA, a region which confers cyclic nucleotide regulation of message decay. Seems to play a role in PML-nuclear bodies formation. |
| Protein Name | Serpine1 Mrna-Binding Protein 1Pai1 Rna-Binding Protein 1Pai-Rbp1Plasminogen Activator Inhibitor 1 Rna-Binding Protein |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusPerinuclear Region |
| Alternative Antibody Names | Anti-Serpine1 Mrna-Binding Protein 1 antibodyAnti-Pai1 Rna-Binding Protein 1 antibodyAnti-Pai-Rbp1 antibodyAnti-Plasminogen Activator Inhibitor 1 Rna-Binding Protein antibodyAnti-SERBP1 antibodyAnti-PAIRBP1 antibodyAnti-CGI-55 antibody |
Information sourced from Uniprot.org