Anti-SEPT7 antibody (Internal) (STJ71735)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-SEPT7 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog/Pig/Cow/Horse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 45kDa band observed in nuclear lysates of cell line HeLa (calculated MW of 50.7kDa according to NP_001779.3 and of 55.6kDa according to NP_001011553.2). This molecular weight is |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | SEPTIN7 |
| Gene ID | 989 |
| Uniprot ID | SEPT7_HUMAN |
| Accession Number | NP_001779.3; NP_001011553.2; NP_001229885.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | DNNKNKGQLTKSP |
| Specificity | This antibody is expected to recognize all three reported isoforms (NP_001779.3; NP_001011553.2; NP_001229885.1). |
Additional Info
| Function | Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation. |
| Protein Name | Septin-7Cdc10 Protein Homolog |
| Database Links | Reactome: R-HSA-5687128 |
| Cellular Localisation | CytoplasmChromosomeCentromereKinetochoreCytoskeletonSpindleCleavage FurrowMidbodyCilium AxonemeCell ProjectionCiliumFlagellumDistributed Throughout The Cytoplasm In Prometaphase CellsAssociated With The Spindle During MetaphaseAssociated With The Central Spindle And At The Cleavage Furrow In Anaphase CellsDetected At The Midbody In TelophaseAssociated With Actin Stress FibersFound In The Sperm Annulus |
| Alternative Antibody Names | Anti-Septin-7 antibodyAnti-Cdc10 Protein Homolog antibodyAnti-SEPTIN7 antibodyAnti-CDC10 antibodyAnti-SEPT7 antibody |
Information sourced from Uniprot.org