Anti-SEPT6 antibody (Internal) (STJ71734)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-SEPT6 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human/Cow/Dog |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:4000.WB: Approx 50kDa band observed in Human Testis, Duodenum, Kidney and Tonsil lysates, and in lysates of cell lines Daudi, Jurkat and MOLT4 (calculated MW of 49.7kDa according to NP_055944.2) |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | SEPTIN6 |
| Gene ID | 23157 |
| Uniprot ID | SEPT6_HUMAN |
| Accession Number | NP_665798.1; NP_055944.2; NP_665801.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | DEVNAFKQRKTA |
| Specificity | This antibody is expected to recognize the reported isoforms NP_665798.1, NP_055944.2 and NP_665801.1. Reported variants NP_665799.1 and NP_665798.1 represent identical protein. |
Additional Info
| Function | Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Involved in cytokinesis. May play a role in HCV RNA replication. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation. |
| Protein Name | Septin-6 |
| Cellular Localisation | CytoplasmCytoskeletonSpindleChromosomeCentromereKinetochoreCleavage FurrowMidbodyCell ProjectionCiliumFlagellumIn Metaphase CellsLocalized Within The Microtubule SpindleAt The Metaphase PlateIn Close Apposition To The Kinetochores Of The Congressed ChromosomesIn Cells Undergoing CytokinesisLocalized To The MidbodyThe Ingressing Cleavage FurrowAnd The Central SpindleFound In The Sperm Annulus |
| Alternative Antibody Names | Anti-Septin-6 antibodyAnti-SEPTIN6 antibodyAnti-KIAA0128 antibodyAnti-SEP2 antibodyAnti-SEPT6 antibody |
Information sourced from Uniprot.org