Anti-SENP2 antibody [R05-7S7] (STJA0037323)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human SENP2
General Information
| Short Description | Rabbit monoclonal anti-SENP2 for use in WB, IHC-P, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R05-7S7 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Purified |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | SENP2 |
| Gene ID | 59343 |
| Uniprot ID | SENP2_HUMAN |
| Immunogen | A synthesized peptide derived from human SENP2 |
Additional Info
| Post Translational Modifications | Polyubiquitinated.which leads to proteasomal degradation. |
| Function | Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB. Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection. |
| Protein Name | Sentrin-Specific Protease 2Axam2Smt3-Specific Isopeptidase 2Smt3ip2Sentrin/Sumo-Specific Protease Senp2 |
| Database Links | Reactome: R-HSA-3065679 |
| Cellular Localisation | NucleusNuclear Pore ComplexNucleus MembranePeripheral Membrane ProteinNucleoplasmic SideCytoplasmShuttles Between Cytoplasm And Nucleus |
| Alternative Antibody Names | Anti-Sentrin-Specific Protease 2 antibodyAnti-Axam2 antibodyAnti-Smt3-Specific Isopeptidase 2 antibodyAnti-Smt3ip2 antibodyAnti-Sentrin/Sumo-Specific Protease Senp2 antibodyAnti-SENP2 antibodyAnti-KIAA1331 antibody |
Information sourced from Uniprot.org