Anti-SENP2 antibody (481-530 aa) (STJ95602)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human SENP2 at the amino acid range 481-530
General Information
| Short Description | Rabbit polyclonal anti-Sentrin-specific protease 2 (481-530 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SENP2 |
| Gene ID | 59343 |
| Uniprot ID | SENP2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human SENP2 at the amino acid range 481-530 |
| Immunogen Region | 481-530 aa |
| Specificity | SENP2 Polyclonal Antibody detects endogenous levels of SENP2 protein. |
Additional Info
| Function | Protease that catalyzes two essential functions in the SUMO pathway. The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins. The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein. May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB. Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection. |
| Protein Name | Sentrin-Specific Protease 2Axam2Smt3-Specific Isopeptidase 2Smt3ip2Sentrin/Sumo-Specific Protease Senp2 |
| Database Links | Reactome: R-HSA-3065679 |
| Cellular Localisation | NucleusNuclear Pore ComplexNucleus MembranePeripheral Membrane ProteinNucleoplasmic SideCytoplasmShuttles Between Cytoplasm And Nucleus |
| Alternative Antibody Names | Anti-Sentrin-Specific Protease 2 antibodyAnti-Axam2 antibodyAnti-Smt3-Specific Isopeptidase 2 antibodyAnti-Smt3ip2 antibodyAnti-Sentrin/Sumo-Specific Protease Senp2 antibodyAnti-SENP2 antibodyAnti-KIAA1331 antibody |
Information sourced from Uniprot.org