| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SEMG1 (24-310) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SEMG1 |
| Gene ID: |
6406 |
| Uniprot ID: |
SEMG1_HUMAN |
| Immunogen Region: |
24-310 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 24-310 of human SEMG1 (NP_002998.1). |
| Immunogen Sequence: |
QKGGSKGRLPSEFSQFPHGQ KGQHYSGQKGKQQTESKGSF SIQYTYHVDANDHDQSRKSQ QYDLNALHKTTKSQRHLGGS QQLLHNKQEGRDHDKSKGHF HRVVIHHKGGKAHRGTQNPS QDQGNSPSGKGISSQYSNTE ERLWVHGLSKEQTSVSGAQK GRKQGGSQSSYVLQTEELVA NKQQRETKNSHQNKGHYQNV VEVREEHSSKVQTSLCPAHQ DKLQHGSKDIFSTQDELLV |
| Tissue Specificity | Seminal vesicle. |
| Post Translational Modifications | Transglutaminase substrate. Rapidly cleaved after ejaculation by KLK3/PSA, resulting in liquefaction of the semen coagulum and the progressive release of motile spermatozoa. |
| Function | Predominant protein in semen. It participates in the formation of a gel matrix entrapping the accessory gland secretions and ejaculated spermatozoa. Fragments of semenogelin and/or fragments of the related proteins may contribute to the activation of progressive sperm movements as the gel-forming proteins are fragmented by KLK3/PSA. Alpha-inhibin-92 and alpha-inhibin-31, derived from the proteolytic degradation of semenogelin, inhibit the secretion of pituitary follicle-stimulating hormone. |
| Protein Name | Semenogelin-1Cancer/Testis Antigen 103Semenogelin ISgi Cleaved Into - Alpha-Inhibin-92 - Alpha-Inhibin-31 - Seminal Basic Protein |
| Database Links | Reactome: R-HSA-6803157Reactome: R-HSA-977225 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Semenogelin-1 antibodyAnti-Cancer/Testis Antigen 103 antibodyAnti-Semenogelin I antibodyAnti-Sgi Cleaved Into - Alpha-Inhibin-92 - Alpha-Inhibin-31 - Seminal Basic Protein antibodyAnti-SEMG1 antibodyAnti-SEMG antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
