Anti-Semaphorin-3E antibody (N-Term) (STJA0041405)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSema-3E (N-terminal region) synthetic peptide (coupled to carrier protein) corresponds to amino acids in the N-terminal region of human Sema-3E. This sequence is well conserved in rat, mouse, and chicken Sema-3E, and has low homology to other semapho
General Information
| Short Description | Rabbit polyclonal anti-Semaphorin-3E (N-Term) for use in ELISA and WB in Chicken, Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB |
| Host | Rabbit |
| Reactivity | Chicken/Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Antigen Affinity Purified |
| Dilution Range | WB 1:1000 |
| Formulation | PBS + 0.05% NaN3 |
| Storage Instruction | Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at-20°C C or-80°C C, while keeping a working aliquot stored at 4°C C for short term. Avoid freeze/t |
Target Information
| Gene Symbol | SEMA3E |
| Gene ID | 9723 |
| Uniprot ID | SEM3E_HUMAN |
| Immunogen | Sema-3E (N-terminal region) synthetic peptide (coupled to carrier protein) corresponds to amino acids in the N-terminal region of human Sema-3E. This sequence is well conserved in rat, mouse, and chicken Sema-3E, and has low homology to other semapho |
| Immunogen Region | N-Term |
| Immunogen Sequence | Human |
| Specificity | The antibody detects 87 and 61 kDa bands corresponding to the full-length and furin-proccessed forms of Sema-3E in human PC-3 and rat PC12 cells. |
Additional Info
| Function | Plays an important role in signaling via the cell surface receptor PLXND1. Mediates reorganization of the actin cytoskeleton, leading to the retraction of cell projections. Promotes focal adhesion disassembly and inhibits adhesion of endothelial cells to the extracellular matrix. Regulates angiogenesis, both during embryogenesis and after birth. Can down-regulate sprouting angiogenesis. Required for normal vascular patterning during embryogenesis. Plays an important role in ensuring the specificity of synapse formation. |
| Protein Name | Semaphorin-3e |
| Database Links | Reactome: R-HSA-416700 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Semaphorin-3e antibodyAnti-SEMA3E antibodyAnti-KIAA0331 antibodyAnti-SEMAH antibody |
Information sourced from Uniprot.org