| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SELP (220-319) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SELP |
| Gene ID: |
6403 |
| Uniprot ID: |
LYAM3_HUMAN |
| Immunogen Region: |
220-319 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 220-319 of human CD62P/P-selectin (NP_002996.2). |
| Immunogen Sequence: |
FSFNSQCSFHCTDGYQVNGP SKLECLASGIWTNKPPQCLA AQCPPLKIPERGNMTCLHSA KAFQHQSSCSFSCEEGFALV GPEVVQCTASGVWTAPAPVC |
| Tissue Specificity | Stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. Upon cell activation by agonists, P-selectin is transported rapidly to the cell surface. |
| Function | Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. |
| Protein Name | P-SelectinCd62 Antigen-Like Family Member PGranule Membrane Protein 140Gmp-140Leukocyte-Endothelial Cell Adhesion Molecule 3Lecam3Platelet Activation Dependent Granule-External Membrane ProteinPadgemCd Antigen Cd62p |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-202733 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-P-Selectin antibodyAnti-Cd62 Antigen-Like Family Member P antibodyAnti-Granule Membrane Protein 140 antibodyAnti-Gmp-140 antibodyAnti-Leukocyte-Endothelial Cell Adhesion Molecule 3 antibodyAnti-Lecam3 antibodyAnti-Platelet Activation Dependent Granule-External Membrane Protein antibodyAnti-Padgem antibodyAnti-Cd Antigen Cd62p antibodyAnti-SELP antibodyAnti-GMRP antibodyAnti-GRMP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
