Anti-SELENON antibody (STJA0007009)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SEPN1
General Information
| Short Description | Rabbit polyclonal anti-Selenoprotein N for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SELENON |
| Gene ID | 57190 |
| Uniprot ID | SELN_HUMAN |
| Immunogen | Synthesized peptide derived from human SEPN1 |
| Specificity | This antibody detects endogenous levels of SEPN1 at Human |
Additional Info
| Post Translational Modifications | Isoform 2: N-glycosylated. |
| Function | Isoform 2: Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity. Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation. Essential for muscle regeneration and satellite cell maintenance in skeletal muscle. |
| Protein Name | Selenoprotein NSeln |
| Database Links | |
| Cellular Localisation | Isoform 2: Endoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Selenoprotein N antibodyAnti-Seln antibodyAnti-SELENON antibodyAnti-SELN antibodyAnti-SEPN1 antibody |
Information sourced from Uniprot.org