| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Dog/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-SEL1L (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:1000.WB: Approx 80kDa band observed in lysates of cell line HepG2 (calculated MW of 88.8kDa according to NP_005056.3). Recommended concentration: 1-3µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | SEL1L |
| Gene ID: | 6400 |
| Uniprot ID: | SE1L1_HUMAN |
| Immunogen Region: | Internal |
| Accession Number: | NP_005056.3 |
| Immunogen Sequence: | TAYNSYKDGDYN |
| Post Translational Modifications | N-glycosylated. |
| Function | Plays a role in the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Enhances SYVN1 stability. Plays a role in LPL maturation and secretion. Required for normal differentiation of the pancreas epithelium, and for normal exocrine function and survival of pancreatic cells. May play a role in Notch signaling. |
| Protein Name | Protein Sel-1 Homolog 1Suppressor Of Lin-12-Like Protein 1Sel-1l |
| Database Links | Reactome: R-HSA-1912420Reactome: R-HSA-382556Reactome: R-HSA-5358346Reactome: R-HSA-5362768Reactome: R-HSA-5678895Reactome: R-HSA-901032 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Protein Sel-1 Homolog 1 antibodyAnti-Suppressor Of Lin-12-Like Protein 1 antibodyAnti-Sel-1l antibodyAnti-SEL1L antibodyAnti-TSA305 antibodyAnti-UNQ128 antibodyAnti-PRO1063 antibody |
Information sourced from Uniprot.org
