Anti-SEC63 antibody (595-720) (STJ11103377)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SEC63 (595-720) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SEC63 |
| Gene ID | 11231 |
| Uniprot ID | SEC63_HUMAN |
| Immunogen Region | 595-720 |
| Immunogen Sequence | RDSDREQDEKQNKDDEAEWQ ELQQSIQRKERALLETKSKI THPVYSLYFPEEKQEWWWLY IADRKEQTLISMPYHVCTLK DTEEVELKFPAPGKPGNYQY TVFLRSDSYMGLDQIKPLKL EVHEAK |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 595-720 of human SEC63 (NP_009145.1). |
Additional Info
| Tissue Specificity | Widely expressed, with high levels in the liver. |
| Function | Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia. |
| Protein Name | Translocation Protein Sec63 HomologDnaj Homolog Subfamily C Member 23 |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Translocation Protein Sec63 Homolog antibodyAnti-Dnaj Homolog Subfamily C Member 23 antibodyAnti-SEC63 antibodyAnti-DNAJC23 antibodyAnti-SEC63L antibody |
Information sourced from Uniprot.org