| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SEC63 |
| Gene ID: | 11231 |
| Uniprot ID: | SEC63_HUMAN |
| Immunogen Region: | 595-720 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 595-720 of human SEC63 (NP_009145.1). |
| Immunogen Sequence: | RDSDREQDEKQNKDDEAEWQ ELQQSIQRKERALLETKSKI THPVYSLYFPEEKQEWWWLY IADRKEQTLISMPYHVCTLK DTEEVELKFPAPGKPGNYQY TVFLRSDSYMGLDQIKPLKL EVHEAK |
| Tissue Specificity | Widely expressed, with high levels in the liver. |
| Function | Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER). Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia. |
| Protein Name | Translocation Protein Sec63 Homolog Dnaj Homolog Subfamily C Member 23 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Translocation Protein Sec63 Homolog antibody Anti-Dnaj Homolog Subfamily C Member 23 antibody Anti-SEC63 antibody Anti-DNAJC23 antibody Anti-SEC63L antibody |
Information sourced from Uniprot.org