Anti-SDCBP antibody (STJA0010215)

SKU:
STJA0010215

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Rat/Dog/Pig
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Syntenin-1 is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:1000-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SDCBP
Gene ID: 6386
Uniprot ID: SDCB1_HUMAN
Specificity: This antibody detects endogenous levels of Human, Rat, Dog, Pig syntenin
Immunogen: Synthesized peptide derived from human syntenin
Tissue Specificity Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma (at protein level). Widely expressed. Expressed in fetal kidney, liver, lung and brain. In adult highest expression in heart and placenta.
Post Translational Modifications Phosphorylated on tyrosine residues.
Function Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis. Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1. In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis. Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.
Protein Name Syntenin-1
Melanoma Differentiation-Associated Protein 9
Mda-9
Pro-Tgf-Alpha Cytoplasmic Domain-Interacting Protein 18
Tacip18
Scaffold Protein Pbp1
Syndecan-Binding Protein 1
Database Links Reactome: R-HSA-3928664
Reactome: R-HSA-447043
Reactome: R-HSA-5213460
Reactome: R-HSA-5675482
Reactome: R-HSA-6798695
Cellular Localisation Cell Junction
Focal Adhesion
Adherens Junction
Cell Membrane
Peripheral Membrane Protein
Endoplasmic Reticulum Membrane
Nucleus
Melanosome
Cytoplasm
Cytosol
Cytoskeleton
Secreted
Extracellular Exosome
Membrane Raft
Mainly Membrane-Associated
Localized To Adherens Junctions
Focal Adhesions And Endoplasmic Reticulum
Colocalized With Actin Stress Fibers
Also Found In The Nucleus
Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
Associated To The Plasma Membrane In The Presence Of Fzd7 And Phosphatidylinositol 4
5-Bisphosphate (Pip2)
Alternative Antibody Names Anti-Syntenin-1 antibody
Anti-Melanoma Differentiation-Associated Protein 9 antibody
Anti-Mda-9 antibody
Anti-Pro-Tgf-Alpha Cytoplasmic Domain-Interacting Protein 18 antibody
Anti-Tacip18 antibody
Anti-Scaffold Protein Pbp1 antibody
Anti-Syndecan-Binding Protein 1 antibody
Anti-SDCBP antibody
Anti-MDA9 antibody
Anti-SYCL antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance