Anti-SDC4 antibody (19-145) (STJ25459)

Name: Anti-SDC4 antibody (19-145) (STJ25459)
SKU: STJ25459
Availability: InStock

⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ25459

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Short Description	Rabbit polyclonal SDC4 (19-145) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.09% Sodium Azide, 50% Glycerol, pH7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	SDC4
Gene ID	6385
Uniprot ID	SDC4_HUMAN
Immunogen Region	19-145
Immunogen Sequence	ESIRETEVIDPQDLLEGRYF SGALPDDEDVVGPGQESDDF ELSGSGDLDDLEDSMIGPEV VHPLVPLDNHIPERAGSGSQ VPTEPKKLEENEVIPKRISP VEESEDVSNKVSMSSTVQGS NIFERTE
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 19-145 of human SDC4 (NP_002990.2).

Tissue Specificity	Detected in fibroblasts (at protein level). Also expressed in epithelial cells.
Post Translational Modifications	Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3. O-glycosylated.contains both chondroitin sulfate and heparan sulfate. Ser-39, Ser-61 and Ser-63 can all be modified by either chondroitin sulfate or heparan sulfate, and the protein exists in forms that contain only chondroitin sulfate, only heparan sulfate and both chondroitin sulfate and heparan sulfate.
Function	Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP.
Protein Name	Syndecan-4 Synd4 Amphiglycan Ryudocan Core Protein
Database Links	Reactome: R-HSA-1971475 Reactome: R-HSA-2022928 Reactome: R-HSA-2024096 Reactome: R-HSA-202733 Reactome: R-HSA-3000170 Reactome: R-HSA-3560783 Reactome: R-HSA-3560801 Reactome: R-HSA-3656237 Reactome: R-HSA-3656253 Reactome: R-HSA-4420332 Reactome: R-HSA-9694614 Reactome: R-HSA-975634 Reactome: R-HSA-9820960 Reactome: R-HSA-9833110
Cellular Localisation	Isoform 1: Membrane Single-Pass Type I Membrane Protein Secreted Shedding Of The Ectodomain Produces A Soluble Form Isoform 2: Secreted
Alternative Antibody Names	Anti-Syndecan-4 antibody Anti-Synd4 antibody Anti-Amphiglycan antibody Anti-Ryudocan Core Protein antibody Anti-SDC4 antibody

Information sourced from Uniprot.org