| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | Rabbit polyclonal antibody anti-SDC4 (19-145) is suitable for use in Western Blot research applications. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | SDC4 |
| Gene ID: | 6385 |
| Uniprot ID: | SDC4_HUMAN |
| Immunogen Region: | 19-145 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 19-145 of human SDC4 (NP_002990.2). |
| Immunogen Sequence: | ESIRETEVIDPQDLLEGRYF SGALPDDEDVVGPGQESDDF ELSGSGDLDDLEDSMIGPEV VHPLVPLDNHIPERAGSGSQ VPTEPKKLEENEVIPKRISP VEESEDVSNKVSMSSTVQGS NIFERTE |
| Tissue Specificity | Detected in fibroblasts (at protein level). Also expressed in epithelial cells. |
| Post Translational Modifications | Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3. O-glycosylated.contains both chondroitin sulfate and heparan sulfate. Ser-39, Ser-61 and Ser-63 can all be modified by either chondroitin sulfate or heparan sulfate, and the protein exists in forms that contain only chondroitin sulfate, only heparan sulfate and both chondroitin sulfate and heparan sulfate. |
| Function | Cell surface proteoglycan which regulates exosome biogenesis in concert with SDCBP and PDCD6IP. |
| Protein Name | Syndecan-4Synd4AmphiglycanRyudocan Core Protein |
| Database Links | Reactome: R-HSA-1971475Reactome: R-HSA-2022928Reactome: R-HSA-2024096Reactome: R-HSA-202733Reactome: R-HSA-3000170Reactome: R-HSA-3560783Reactome: R-HSA-3560801Reactome: R-HSA-3656237Reactome: R-HSA-3656253Reactome: R-HSA-4420332Reactome: R-HSA-9694614Reactome: R-HSA-975634 |
| Cellular Localisation | Isoform 1: MembraneSingle-Pass Type I Membrane ProteinSecretedShedding Of The Ectodomain Produces A Soluble FormIsoform 2: Secreted |
| Alternative Antibody Names | Anti-Syndecan-4 antibodyAnti-Synd4 antibodyAnti-Amphiglycan antibodyAnti-Ryudocan Core Protein antibodyAnti-SDC4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
