Anti-SCUBE3 antibody (STJA0008000)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human SCUBE3
General Information
| Short Description | Rabbit polyclonal anti-Signal peptide, CUB and EGF-like domain-containing protein 3 for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SCUBE3 |
| Gene ID | 222663 |
| Uniprot ID | SCUB3_HUMAN |
| Immunogen | Synthesized peptide derived from human SCUBE3 |
| Specificity | This antibody detects endogenous levels of SCUBE3 at Human, Mouse |
Additional Info
| Post Translational Modifications | N-glycosylated. Proteolytic cleavage produces a CUB-containing C-terminal fragment that retains the ability to bind to TGFBR2. This reaction is catalyzed in vitro by MMP2 and, to a lesser extent, by MMP9. |
| Function | Is a positive regulator of the BMP signaling pathway, required for proper chondrogenesis, osteogenesis and skeletal development. It acts as a coreceptor for BMP ligands, particularly BMP2 and BMP4, facilitating their interactions with BMP type I receptors. It is required for ligand-induced recruitment of BMP receptors to lipid rafts. Binds to TGFBR2 and activates TGFB signaling. In lung cancer cells, could serve as an endogenous autocrine and paracrine ligand of TGFBR2, which could regulate TGFBR2 signaling and hence modulate epithelial-mesenchymal transition and cancer progression. |
| Protein Name | Signal Peptide - Cub And Egf-Like Domain-Containing Protein 3 |
| Database Links | Reactome: R-HSA-1474228 |
| Cellular Localisation | SecretedCell Surface |
| Alternative Antibody Names | Anti-Signal Peptide - Cub And Egf-Like Domain-Containing Protein 3 antibodyAnti-SCUBE3 antibodyAnti-CEGF3 antibody |
Information sourced from Uniprot.org