Anti-SCO2 antibody (100-266) (STJ29131)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal SCO2 (100-266) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | SCO2 |
| Gene ID | 9997 |
| Uniprot ID | SCO2_HUMAN |
| Immunogen Region | 100-266 |
| Immunogen Sequence | GQGDFHLLDHRGRARCKADF RGQWVLMYFGFTHCPDICPD ELEKLVQVVRQLEAEPGLPP VQPVFITVDPERDDVEAMAR YVQDFHPRLLGLTGSTKQVA QASHSYRVYYNAGPKDEDQD YIVDHSIAIYLLNPDGLFTD YYGRSRSAEQISDSVRRHMA AFRSVLS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 100-266 of human SCO2 (NP_005129.2). |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Function | Copper metallochaperone essential for the synthesis and maturation of cytochrome c oxidase subunit II (MT-CO2/COX2) by facilitating the incorporation of copper into the Cu(A) site of MT-CO2/COX2. Could also act as a thiol-disulfide oxidoreductase to regulate the redox state of the cysteines in SCO1 during maturation of MT-CO2/COX2. |
| Protein Name | Protein Sco2 Homolog - Mitochondrial |
| Database Links | Reactome: R-HSA-5628897Reactome: R-HSA-9864848 |
| Cellular Localisation | Mitochondrion Inner MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Protein Sco2 Homolog - Mitochondrial antibodyAnti-SCO2 antibody |
Information sourced from Uniprot.org