Anti-SCNN1G antibody (C-Term) (STJ71750)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-SCNN1G (C-Term) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/IHC |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Preliminary experiments gave an approx 140kDa band in Human Breast cancer and Colon lysates after 1µg/ml antibody staining. Please note that currently we cannot find an explanation in |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | SCNN1G |
| Gene ID | 6340 |
| Uniprot ID | SCNNG_HUMAN |
| Accession Number | NP_001030.2 |
| Immunogen Region | C-Term |
| Immunogen Sequence | SNQLTDTQMLDE |
Additional Info
| Post Translational Modifications | Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation. Ubiquitinated.this targets individual subunits for endocytosis and proteasome-mediated degradation. ENaC cleavage by furin, and subsequently by prostasin (PRSS8), leads to a stepwise increase in the open probability of the channel as a result of release of the alpha and gamma subunit inhibitory tracts, respectively. Interaction of ENaC subunit SCNN1B with BPIFA1 protects ENaC against proteolytic activation. |
| Function | Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. |
| Protein Name | Amiloride-Sensitive Sodium Channel Subunit GammaEpithelial Na(+ Channel Subunit GammaEnacgGamma-EnacGamma-NachNonvoltage-Gated Sodium Channel 1 Subunit GammaScneg |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-9730628 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinApical Membrane Of Epithelial Cells |
| Alternative Antibody Names | Anti-Amiloride-Sensitive Sodium Channel Subunit Gamma antibodyAnti-Epithelial Na(+ Channel Subunit Gamma antibodyAnti-Enacg antibodyAnti-Gamma-Enac antibodyAnti-Gamma-Nach antibodyAnti-Nonvoltage-Gated Sodium Channel 1 Subunit Gamma antibodyAnti-Scneg antibodyAnti-SCNN1G antibody |
Information sourced from Uniprot.org