| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-SCNN1G (100-250) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
SCNN1G |
| Gene ID: |
6340 |
| Uniprot ID: |
SCNNG_HUMAN |
| Immunogen Region: |
100-250 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 100-250 of human SCNN1G (NP_001030.2). |
| Immunogen Sequence: |
CNINPYKYSTVRHLLADLEQ ETREALKSLYGFPESRKRRE AESWNSVSEGKQPRFSHRIP LLIFDQDEKGKARDFFTGRK RKVGGSIIHKASNVMHIESK QVVGFQLCSNDTSDCATYTF SSGINAIQEWYKLHYMNIMA QVPLEKKINMS |
| Tissue Specificity | Expressed in kidney (at protein level). |
| Post Translational Modifications | Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation. Ubiquitinated.this targets individual subunits for endocytosis and proteasome-mediated degradation. ENaC cleavage by furin, and subsequently by prostasin (PRSS8), leads to a stepwise increase in the open probability of the channel as a result of release of the alpha and gamma subunit inhibitory tracts, respectively. Interaction of ENaC subunit SCNN1B with BPIFA1 protects ENaC against proteolytic activation. |
| Function | Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. |
| Protein Name | Amiloride-Sensitive Sodium Channel Subunit GammaEpithelial Na(+ Channel Subunit GammaEnacgGamma-EnacGamma-NachNonvoltage-Gated Sodium Channel 1 Subunit GammaScneg |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-9730628 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinApical Membrane Of Epithelial Cells |
| Alternative Antibody Names | Anti-Amiloride-Sensitive Sodium Channel Subunit Gamma antibodyAnti-Epithelial Na(+ Channel Subunit Gamma antibodyAnti-Enacg antibodyAnti-Gamma-Enac antibodyAnti-Gamma-Nach antibodyAnti-Nonvoltage-Gated Sodium Channel 1 Subunit Gamma antibodyAnti-Scneg antibodyAnti-SCNN1G antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
