Anti-SCNN1D antibody (STJ13101763)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from the extracellular domain of human amiloride sensitive sodium channel subunit delta (SCNN1D, SCNED, Delta-ENaC) conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-SCNN1D for use in IHC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | SCNN1D |
| Gene ID | 6339 |
| Uniprot ID | SCNND_HUMAN |
| Immunogen | A synthetic peptide from the extracellular domain of human amiloride sensitive sodium channel subunit delta (SCNN1D, SCNED, Delta-ENaC) conjugated to an immunogenic carrier protein was used as the antigen. |
| Specificity | Specific for SCNN1D. |
Additional Info
| Function | Potential alternative pore-forming subunit of the epithelial sodium channel (ENaC), capable of replacing the alpha/SCNN1A subunit, creating a more active channel with distinct properties. ENaC functions in epithelial tissues, where it facilitates the electrodiffusion of sodium ions from the extracellular fluid through the apical membrane of cells, with water following osmotically, regulating sodium balance and fluid homeostasis. This subunit could also function independently as a sodium channel or assemble into other tissue-specific heterotrimeric sodium channels. Isoform 2: ENaC channels including this isoform exhibit greater conductance. |
| Protein Name | Epithelial Sodium Channel Subunit DeltaDelta-EnacEnacdEpithelial Na(+ Channel Subunit DeltaAmiloride-Sensitive Sodium Channel Subunit DeltaDelta-NachNonvoltage-Gated Sodium Channel 1 Subunit DeltaScned |
| Database Links | Reactome: R-HSA-2672351Reactome: R-HSA-9730628 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Epithelial Sodium Channel Subunit Delta antibodyAnti-Delta-Enac antibodyAnti-Enacd antibodyAnti-Epithelial Na(+ Channel Subunit Delta antibodyAnti-Amiloride-Sensitive Sodium Channel Subunit Delta antibodyAnti-Delta-Nach antibodyAnti-Nonvoltage-Gated Sodium Channel 1 Subunit Delta antibodyAnti-Scned antibodyAnti-SCNN1D antibodyAnti-DNACH antibody |
Information sourced from Uniprot.org