Anti-SCNN1A antibody (320-400 aa) (STJ190541)

SKU:
STJ190541

Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Amiloride-sensitive sodium channel subunit alpha channel subunit alpha (320-400 aa) is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:5000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: SCNN1A
Gene ID: 6337
Uniprot ID: SCNNA_HUMAN
Immunogen Region: 320-400 aa
Specificity: SCNNA Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from the human protein at the amino acid range 320-400
Post Translational Modifications Ubiquitinated.this targets individual subunits for endocytosis and proteasome-mediated degradation. ENaC cleavage by furin, and subsequently by prostasin (PRSS8), leads to a stepwise increase in the open probability of the channel as a result of release of the alpha and gamma subunit inhibitory tracts, respectively. Interaction of ENaC subunit SCNN1B with BPIFA1 protects ENaC against proteolytic activation. N-glycosylated.
Function Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and eccrine sweat glands. Also plays a role in taste perception.
Protein Name Amiloride-Sensitive Sodium Channel Subunit Alpha
Alpha-Nach
Epithelial Na(+ Channel Subunit Alpha
Alpha-Enac
Enaca
Nonvoltage-Gated Sodium Channel 1 Subunit Alpha
Scnea
Database Links Reactome: R-HSA-2672351
Reactome: R-HSA-9730628
Cellular Localisation Apical Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Cilium
Cytoplasmic Granule
Cytoplasm
Cytoplasmic Vesicle
Secretory Vesicle
Acrosome
Flagellum
In The Oviduct And Bronchus
Located On Cilia In Multi-Ciliated Cells
In Endometrial Non-Ciliated Epithelial Cells
Restricted To Apical Surfaces
In Epidermis
Located Nearly Uniformly In The Cytoplasm In A Granular Distribution
In Sebaceous Glands
Observed Only In The Cytoplasmic Space In Between The Lipid Vesicles
In Eccrine Sweat Glands
Mainly Located At The Apical Surface Of The Cells Facing The Lumen
In Skin
In Arrector Pili Muscle Cells And In Adipocytes
Located In The Cytoplasm And Colocalized With Actin Fibers
In Spermatogonia
Spermatocytes And Round Spermatids
Located In The Cytoplasm
Prior To Spermiation
Location Shifts From The Cytoplasm To The Spermatid Tail
In Spermatozoa
Localizes At The Acrosome And The Central Region Of The Sperm Flagellum
Alternative Antibody Names Anti-Amiloride-Sensitive Sodium Channel Subunit Alpha antibody
Anti-Alpha-Nach antibody
Anti-Epithelial Na(+ Channel Subunit Alpha antibody
Anti-Alpha-Enac antibody
Anti-Enaca antibody
Anti-Nonvoltage-Gated Sodium Channel 1 Subunit Alpha antibody
Anti-Scnea antibody
Anti-SCNN1A antibody
Anti-SCNN1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance